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KMID : 0379519990150030389
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한국독성학회지
1999 Volume.15 No. 3 p.389 ~ p.393
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Local Toxicity of DA-7101, A Novel Combined Antibiotic (Cefatrizine/Clavulanic Acid), in Albino Rabbits
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Kim Dong-Hwan
Cho Hyun
Ahn Byoung-Ok
Kim Won-Bae
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Abstract
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Primary skin irritation and eye irritation of a new oral combined antibiotic, cefatrizine/clavulantic acid (CFT/CVA, DA-710l), were investigated in albino rabbits. In primary skin irritation study, a single dermal application of CFT/CVA at a dose of 500 mg showed no irritancy on intact skin and very slight erythema and edema on scarified skin (PII=0.46). In eye irritation study, a single intraconjunctival application of 100 mg of CFT/CVA resulted in mild and reversible reactions such as redness and chemosis of conjunctivae, which were disappeared 72 h after the application. The AOI values were 3 and 2.7 for nonirrigation and irrigation, respectively. The present study demonstrates that a single administration of CFT/ CVA to the skin and ocular mucosa is not likely to induce significant local irritation effects.
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KEYWORD
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Combined antibiotic, Cefatrizine, Clavulanic acid, Local irritation, Rabbit
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